Chronic Obstructive Pulmonary Disease (COPD) is the major cause of death worldwide. It is projected

to be third leading cause of death globally by 2030.Reactive oxygen species plays important role in patho

physiology of COPD. High ROS generation resulted in increased lipid peroxidation.MDA which is a

biomarker to evaluate the level of lipid peroxidation is used to evaluate the oxidant antioxidant level in

COPD patients. Significant difference between COPD patients and healthy subjects is found in our study. It

is concluded therefore, that a biomarker-based (preferably MDA) study can be utilized to assess the efficacy

of novel antioxidant or other agents in modifying the course of this disease.