Thesis on Oxidative Stress and "chronic obstructive pulmonary disease"

Paper title
Oxidative Stress in Chronic Obstructive Pulmonary Disease
Abstract summary
Oxidative stress has been related to increased expression of proinflammatory genes.
Authors
Mariana A. Antunes, Fernanda F. Cruz, Patricia R.M. Rocco
Journal
Oxidative Stress in Lung Diseases
Semantic Scholar URL
https://semanticscholar.org/paper/5da8a15217e39cdbb13c3a4c156831256fbc15d8
Abstract

Chronic obstructive pulmonary disease (COPD), which comprises chronic bronchitis and emphysema phenotypes, is characterized by airflow obstruction and pulmonary inflammation and tissue disruption. It is also associated with several extrapulmonary manifestations and frequently occurs simultaneously with other disorders that have an additive influence on patients’ quality of life. COPD is usually a disease of aging, and the main risk factor for its development is smoking. A particularly remarkable etiologic factor that drives COPD pathogenesis is oxidative and carbonyl stress which originates in the pulmonary milieu after prolonged exposure to cigarette smoke or to the by-products of combustion of biomass fuels. The fact that COPD progresses even after smoking cessation is probably attributable to numerous exogenous and, especially, endogenous sources of reactive oxygen species (ROS), although this involvement has yet to be proven. The function of key cells, as well as the levels of significant oxidant and antioxidant molecules, may be dysregulated in COPD. Oxidative stress has been related to increased expression of proinflammatory genes, inability to resolve inflammation, insensitivity to corticosteroids, impairment of endogenous antioxidant defenses, accelerated lung senescence, and elevated risk of developing emphysema.

SUPALIV
3tablets
After drinking
SUPALIV

SUPALIV
3 tablets 5sets

US$ 16

SUPALIV
3tablets
After drinking
SUPALIV

SUPALIV
100 tablets

US$ 92

TwendeeX
3tablets every day
for antioxidant
TwendeeX

Twendee X
100 tablets

US$ 49

MtControl
3tablets every day
for antioxidant and beauty
MtControl

Twendee MTCONTROL
100 tablets

US$ 62