Thesis on Oxidative Stress and "heart failure"

Paper title
Oxidative stress and ischemic myocardial syndromes.
Abstract summary
The defense mechanisms of cardiac myocytes are altered during myocardial oxidative stress.
Authors
M. K. Misra, M. Sarwat, Pushpa Bhakuni, R. Tuteja, N. Tuteja
Journal
Medical Science Monitor
Semantic Scholar URL
https://semanticscholar.org/paper/b1f1e62040487e802c8dff3a7c490a6ffaf7ec61
Abstract

Oxidative stress is a condition in which reactive oxygen species (ROS) or free radicals, namely O2*(-), H2O2, and *OH, are generated extra- or intracellularly and exert toxic effects on cells. The heart is one of the major organs affected by ROS. Recent evidence suggests that oxidative stress is a common denominator in many aspects of cardiovascular diseases. During myocardial oxidative stress, the generation of ROS is enhanced and the defense mechanisms of myocytes are altered. The sources of ROS in cardiac myocytes could be mitochondrial electron transport chain, nitric oxide synthase (NOS), NADPH oxidase, xanthine oxidase, and lipoxygenase/cyclooxygenase and the auto-oxidation of various substances, particularly catecholamines. In acute myocardial infarction (AMI), two distinct types of damage occur to the heart: ischemic injury and reperfusion injury, which lead to mitochondrial dysfunction in heart cells. During ischemia and reperfusion, ROS can be produced by both endothelial cells and circulating phagocytes. Ischemia also causes alterations in the defense mechanisms against ROS. Some proteins, including heat-shock proteins, are overexpressed in conditions of ischemia/reperfusion and can protect from cardiac injury. This article outlines the current understanding of oxidative stress and ROS generation and their role in cardiovascular diseases, including ischemic myocardial syndromes. The following aspects are covered: oxidative stress, mitochondrial dysfunction and pathophysiological mechanisms of atherosclerosis, precipitation of MI, sources of ROS in cardiac myocytes, effects of ROS in the heart, and ischemia and reperfusion injuries and their mechanisms.

TwendeeX
3tablets every day
for antioxidant
TwendeeX

Twendee X
100 tablets

US$ 49

MtControl
3tablets every day
for antioxidant and beauty
MtControl

Twendee MTCONTROL
100 tablets

US$ 62

SUPALIV
3tablets
After drinking
SUPALIV

SUPALIV
100 tablets

US$ 74

SUPALIV
3tablets
After drinking
SUPALIV

SUPALIV
3 tablets 5sets

US$ 16