Thesis on Oxidative Stress and "arteriosclerosis"

Paper title
Oxidative stress and diabetic cardiovascular complications.
Abstract summary
Oxidative stress has been demonstrated to be present in animal models as well as in patients with diabetes.
Authors
Desmond Jay, Hirofumi Hitomi, Kathy K Griendling
Journal
Free radical biology & medicine
Semantic Scholar URL
https://semanticscholar.org/paper/f475bf79e5147dd5ae9c4428282803f77d2364ae
Abstract

Diabetes diagnoses are increasing at an alarming rate worldwide. The majority of diabetes-related deaths arise from cardiovascular complications such as myocardial infarction, stroke, and peripheral vascular disease. Oxidative stress has been demonstrated to be present in animal models as well as in patients with diabetes and has been suggested as a possible contributor to the accelerated atherosclerosis seen in diabetics. The generation of reactive oxygen species in diabetes occurs via several mechanisms and is initiated not only by glucose, but also by other substances that are found at elevated levels in diabetic patients. The resulting oxidative stress leads to a number of proatherogenic events. The elucidation of the mechanisms of oxidative stress in diabetes and their relationship with atherosclerosis could potentially identify molecular targets of therapy for this condition and its cardiovascular consequences.

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