Thesis on Oxidative Stress and "chronic obstructive pulmonary disease"

Paper title: Is oxidative stress associated with disease severity, pulmonary function and metabolic syndrome in chronic obstructive pulmonary disease?

Abstract summary: Advanced oxidation protein products are associated with COPD severity and pulmonary function in individuals with COPD.

Authors: W A Sepúlveda Loyola, F Vilaça Cavallari Machado, L Araújo de Castro, T Hissnauer Leal Baltus, N Rampazzo Morelli, K Landucci Bonifácio, A A Morita, A P Michelin, D Sabbatini Barbosa, V S Probst

Journal: Revista clinica espanola

Semantic Scholar URL: https://semanticscholar.org/paper/b609f25d409a00a1a95a2477522926fa06cdfd4d

Abstract

OBJECTIVE

To investigate associations between oxidant/antioxidant biomarkers with the disease severity, pulmonary function and diagnosis of metabolic syndrome (MetS) in patients with COPD.

METHODS

Seventy-four subjects were included, 39 with COPD (age 69±7 years; female 41%) and 35 for control group (age 69±7 years; female 43%). They were diagnosed with MetS and allocated in one of 4 subgroups: COPD and control, with and without MetS, respectively. Advanced oxidation protein products (AOPP), paraoxonase-1, catalase activity, sulfhydryl group and total lipid hydroperoxide were assayed. Pulmonary function was performed with a plethysmograph.

RESULTS

COPD severity (GOLD≥3) and pulmonary function were associated with sulfhydryl group and AOPP (P≤.03 for all). The prevalence of MetS was associated with AOPP in COPD (P=.04). Individuals with COPD and MetS showed higher AOPP compared to COPD without MetS (P<.0001). CONCLUSION COPD severity, worse pulmonary function and presence of metabolic syndrome are associated with oxidative stress in individuals with COPD.