What is brain aging? Can brain cells ever increase?

March 18, 2021

What is brain aging? Can brain cells ever increase?

As the body ages, the brain and brain cells of course age as well. There was a time when it was said that brain cells never grow. However, it is now known that there are newly born nerve cells called newborn nerve cells.

 

In this article, I explain about brain aging, brain cells and oxidative stress.

Cells are born and disappear every day.

Our human body is made up of trillions of cells. In the body, new cells are born and old cells disappear every day, and the cells themselves are replaced. It is also called metabolism, and the period of replacement varies depending on the organ, but anyway, the body frequently creates new cells and replaces the old ones.


In the brain, for example, there are newly born nerve cells called “newborn nerve cells”.

For example, when we are young and in our twenties, there are many new cells, but when we reach our sixties and seventies, the number of new cells decreases to about two-thirds.

The ability of the metabolism to make new cells declines as we get older.


Brain cell aging and oxidative stress

When the ability of metabolism decreases, the number of newly born cells decreases and the body will have more old cells. However, the old cells will die.

It is currently not possible to bring dead cells back to life.


However, animal experiments have shown that by suppressing the body’s rust, oxidative stress, the number of nerve cells produced each day can be maintained at the same level as when the person was young.

Reference “Can cells be revived by lowering oxidative stress?


The data introduced in this reference site is the number of newborn nerve cells in the hippocampal dentate gyrus, a region located deep in the brain of mice.

The number of newborn nerve cells in 6-week-old mice (equivalent to 20 years old), 56-week-old mice (equivalent to 60-70 years old), and 56-week-old mice that were given antioxidants to lower their daily oxidative stress were compared.

In this case, the number of newborn neurons in the mice with reduced oxidative stress was slightly higher than in the 6-week-old mice.

In this way, I think it is very important from the viewpoint of anti-aging to maintain the number of newly generated neurons, rather than to reduce the number of newly generated neurons to zero.

Finally.

Reducing oxidative stress is an effective anti-aging measure. It cannot bring dead cells back to life, but it can reduce the damage to existing cells and maintain the ability to make new cells. In addition, oxidative stress is associated with various diseases, so increasing the body’s antioxidant capacity can help prevent diseases and lead to health and longevity.