Objective: The current study aimed to investigate whether levels of oxidative stress indicators, were altered in chronic pulmonary obstructive disease patients with and without pulmonary hypertension and to examine if oxidative stress markers are correlated with demographic, hematological, biochemical and cardiorespiratory variables. Methods: Thirty chronic pulmonary obstructive disease patients (9 women, 21 men) and 30 healthy controls (20 women, 10 men) were included. Of the 30 patients, 18 (60%) had been diagnosed with pulmonary hypertension. Demographic features, oxygen saturation, hematological, biochemical markers and oxidative stress indicators (catalase activity, glutathione and malondialdehyde levels) were measured and compared in not only chronic pulmonary obstructive disease and control groups, but also in chronic pulmonary obstructive disease patients with and without pulmonary hypertension. Results: In chronic pulmonary obstructive disease patients, serum levels of malondialdehyde were increased; but concentrations of glutathione and catalase were significantly lower. Notably, chronic pulmonary obstructive disease patients with and without pulmonary hypertension did not exhibit any remarkable difference in terms of levels of oxidative stress indicators. An inverse correlation was detected between levels of glutathione and malondialdehyde. Conclusions: To conclude, results of the current study support the roles of inflammation and oxidative stress in chronic pulmonary obstructive disease, but no remarkable alterations in oxidative stress indicators could be identified in chronic pulmonary obstructive disease patients with pulmonary hypertension. Therefore, further trials on larger series are required to elucidate the role of oxidative stress and to assess the effects of antioxidants in chronic pulmonary obstructive disease and pulmonary hypertension. ©2020 The Authors. Published by the JScholar under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/ by/3.0/, which permits unrestricted use, provided the original author and source are credited. J Cardio Vasc Med 2020 | Vol 6: 103 Muntecep Asker, MD1, Selvi Asker MD2,*, Eren Sarikaya MD3 1Department of Cardiology, Van Yuzuncu Yil University Medical Faculty, Van, Turkey 2Department of Chest Diseases, Yuzuncu Yil University Medical Faculty, Van, Turkey 3Department of Chemistry, Van Yuzuncu Yil University, Faculty of Science, Van, Turkey